Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas
نویسندگان
چکیده
Sooman, L. 2014. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 965. 74 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8839-0. The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. To this end, a strategy to evade chemoresistance was evaluated by combining chemotherapeutic drugs with agents inhibiting resistance mechanisms identified by a bioinformatic analysis (paper I). The prognostic value of 13 different proteins was analyzed in this thesis (papers II-IV). Two of them, p38 mitogen-activated protein kinase (MAPK) and protein tyrosine phosphatase non-receptor type 6 (PTPN6, also known as SHP1) were analyzed for their potential as targets in combination chemotherapy (in paper III and IV, respectively).
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